GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (779)
Related Products (779)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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Adinazolam mesylate
0 ImagesCat. No.: HY-A0198ACAS No.: 57938-82-6Synonyms: U 41123F mesylateAdinazolam (U 41123F) mesylate is a triazolobenzodiazepine. Adinazolam mesylate binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. Adinazolam mesylate has dual anxiolytic and antidepressant activities.
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BL-1020 mesylate
0 ImagesCat. No.: HY-111136CAS No.: 916898-61-8BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate.
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iso-Atagabalin hydrochloride
0 ImagesCat. No.: HY-14856ACAS No.: 223445-68-9Synonyms: iso-PD 0200390 hydrochlorideiso-Atagabalin (iso-PD 0200390) hydrochloride is a stereoisomer of Atagabalin (HY-14856). Atagabalin is a selective GABA (gamma-aminobutyric acid) receptor agonist with antianxiety effect.
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SGE-516
0 ImagesCat. No.: HY-129408CAS No.: 1430064-74-6SGE-516 is a neuroactive steroid that is a potent positive allosteric modulator of synaptic and extra-synaptic GABAA receptors. SGE-516 has anticonvulsant activity.
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(S)-SNAP5114 (Standard)
0 ImagesCat. No.: HY-103504RCAS No.: 157604-55-2(S)-SNAP5114 (Standard) is the analytical standard of (S)-SNAP5114 (HY-103504). This product is intended for research and analytical applications. (S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant agent.
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Pitrazepin
0 ImagesCat. No.: HY-183910CAS No.: 90685-01-1Pitrazepin is a GABAA receptor antagonist and glycine receptor antagonist. Pitrazepin blocks synaptic GABA action, induces neuronal bursting and reduces inhibitory postsynaptic potentials. Pitrazepin can be used in research on depression and psychosis.
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ZAPA sulfate (Standard)
0 ImagesZAPA (sulfate) (Standard) is the analytical standard of ZAPA (sulfate) (HY-100799). This product is intended for research and analytical applications. ZAPA sulfate is an agonist at low affinity GABAA-receptors. ZAPA sulfate induces membrane hyperpolarization of the Ascaris muscle cell with an EC50 of 10.3 μM.
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Gaboxadol hydrochloride (Standard)
0 ImagesCat. No.: HY-10233RCAS No.: 85118-33-8Synonyms: Lu 02-030 hydrochloride (Standard); THIP hydrochloride (Standard)Gaboxadol (hydrochloride) (Standard) is the analytical standard of Gaboxadol (hydrochloride). This product is intended for research and analytical applications. Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 μM, a full agonist efficacy at α5 subunit (ED50=28-129 μM) and a superagonist efficacy at α4β3δ (ED50=6 μM). Gaboxadol hydrochloride is a non-opioid agent.
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Gabaculine
0 ImagesCat. No.: HY-N15001CAS No.: 59556-18-2Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable GABA transaminase inhibitor, with an IC50 of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders.
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NNC-711 (Standard)
0 ImagesCat. No.: HY-103506RCAS No.: 145645-62-1Synonyms: NO-711 hydrochloride (Standard)NNC-711 (Standard) is the analytical standard of NNC-711 (HY-103506). This product is intended for research and analytical applications. NNC-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1) with IC50 values of 0.04, 0.38, 171, 1700, 349, 622 μM for human GAT-1, rat GAT-1, rGAT-2, hGAT-3, rGAT-3, hBGT-3, respectively. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity.
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Tigolaner (Standard)
0 ImagesCat. No.: HY-109077RCAS No.: 1621436-41-6Synonyms: BAY-1272858 (Standard)
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Etifoxine hydrochloride (Standard)
0 ImagesSynonyms: HOE 36-801 hydrochloride (Standard)Etifoxine (hydrochloride) (Standard) is the analytical standard of Etifoxine (hydrochloride). This product is intended for research and analytical applications. Etifoxine hydrochloride, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine hydrochloride reveals anxiolytic and anticonvulsant properties in rodents.
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ELB-139
0 ImagesCat. No.: HY-106437CAS No.: 188116-08-7ELB-139 is a progesterone analogue. ELB-139 is a GABAA receptor partial agonist. ELB-139 has anxiolytic and anticonvulsant activity. ELB-139 induces increase of extracellular 5-HT in the striatum and the medial prefrontal cortex of rats.
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Nipecotic acid (Standard)
0 ImagesSynonyms: (±)-β-Homoproline (Standard); Hexahydronicotinic acid (Standard); 3-Carboxypiperidine (Standard)Nipecotic acid (Standard) is the analytical standard of Nipecotic acid. This product is intended for research and analytical applications. Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM.
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epi-Aszonalenin A
0 ImagesCat. No.: HY-135154CAS No.: 908853-14-5epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent.
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Carburazepam
0 ImagesCat. No.: HY-U00241CAS No.: 59009-93-7Synonyms: RGH 3331; UxepamCarburazepam is a agent which derives from benzodiazepine. Benzodiazepines (BZD, BZs) are a class of psychoactive agents whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
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Suclofenide
0 ImagesCat. No.: HY-U00102CAS No.: 30279-49-3Synonyms: Neosulfalepsine; PB385Suclofenide (Neosulfalepsine; PB385) is an anticonvulsant that affects GABA metabolism.
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CGP11952
0 ImagesCat. No.: HY-U00192CAS No.: 64078-09-7CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.
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Ro 41-3290
0 ImagesCat. No.: HY-U00215CAS No.: 143943-72-0Ro 41-3290 is the desethylated derivative of Ro 41-3696, which is a nonbenzodiazepine partial agonist at the benzodiazepine receptor.
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FG8119
0 ImagesCat. No.: HY-U00233CAS No.: 106447-61-4Synonyms: NNC13-8119FG8119 is a novel benzodiazepine agonist extracted from patent US 4745112 A.
